Tri- and Tetravalent Photoactivable Cross-Linking Agents

Alexandre Welle; François Billard; Jacqueline Marchand-Brynaert

doi:10.1055/s-0031-1290444

Synthesis, Table of Contents

Synthesis 2012; 44(14): 2249-2254
DOI: 10.1055/s-0031-1290444

paper

Tri- and Tetravalent Photoactivable Cross-Linking Agents

Authors

Alexandre Welle

Université catholique de Louvain, Institute of Condensed matter and Nanosciences – IMCN / MOST, Bâtiment Lavoisier, place Louis Pasteur L4.01.02, 1348 Louvain-la-Neuve, Belgium, Fax: +32(10)474168 Email: jacqueline.marchand@uclouvain.be
François Billard

Université catholique de Louvain, Institute of Condensed matter and Nanosciences – IMCN / MOST, Bâtiment Lavoisier, place Louis Pasteur L4.01.02, 1348 Louvain-la-Neuve, Belgium, Fax: +32(10)474168 Email: jacqueline.marchand@uclouvain.be
Jacqueline Marchand-Brynaert*

Université catholique de Louvain, Institute of Condensed matter and Nanosciences – IMCN / MOST, Bâtiment Lavoisier, place Louis Pasteur L4.01.02, 1348 Louvain-la-Neuve, Belgium, Fax: +32(10)474168 Email: jacqueline.marchand@uclouvain.be

Abstract

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Abstract

A modular synthesis of photoactivable cross-linking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Symmetrical and nonsymmetrical trivalent structures were obtained from phloroglucinol and dopamine, respectively. Symmetrical tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride.

Key words

ethers - amides - arenes - protecting groups - coupling

Full Text

References

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Supplementary Material

Supporting Information (PDF)